Symbol
Name
ID

Cdkn2b
cyclin dependent kinase inhibitor 2B
MGI:104737

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Abnormal bleeding

Epistaxis

Gingival bleeding

Diffuse alveolar hemorrhage

Oral cavity bleeding

Bruising susceptibility

Purpura

Ecchymosis

Petechiae

Abnormal granulocytopoietic cell morphology

Bone marrow hypercellularity

Pancytopenia

Anemia

Neutropenia

Leukocytosis

Leukopenia

Acute myeloid leukemia

Acute promyelocytic leukemia

Disseminated intravascular coagulation

Hypofibrinogenemia

Thrombocytopenia

Myelodysplasia

Disease(s) Associated with CDKN2B

acute myeloid leukemia

acute promyelocytic leukemia

myelodysplastic syndrome

Mouse Phenotypes

spleen hyperplasia

abnormal common myeloid progenitor cell morphology

myeloid hyperplasia

extramedullary hematopoiesis

decreased erythroid progenitor cell number

abnormal megakaryocyte progenitor cell morphology

increased mature B cell number

increased monocyte cell number

abnormal lymphocyte morphology

abnormal spleen morphology

abnormal spleen marginal zone morphology

Availability

Mouse Genotype

Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd

Cdkn2b^tm1Wff/Cdkn2b^tm1Wff
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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